The article written by S. Masuda et al. has been recently published on journal Organic & Biomolecular Chemistry, showing the results of their research on the synthesis of unprotected peptides in water by ring-closing metathesis (RCM).

Although RCM is an attractive reaction for the preparation of artificially designed peptides, the article entitled "Ring-closing metathesis of unprotected peptides in water" was the very first report of the possibility of unprotected peptides synthesis in water in the presence of Mg (II) ions, without the addition of any organic solvents in RCM which was achieved using a water-soluble ruthenium catalyst - AquaMet, produced by Apeiron Synthesis.

Authors have carried out the optimization of the reaction conditions and showed that the addition of MgCl2 and/or the use of acidic conditions enables the efficient RCM of unprotected model peptides and octreotide analogues in water. That proposed method, the first non-disulphide type connection reaction between homo functionalities in water, with the usage of our catalyst could become a cornerstone of artificial bioactive peptide mimetics development in future.

The full version of article available: here


From February 11-14, 2019 senior technical representatives of Apeiron Synthesis - Anna Gawin and Andrzej Tracz will be present at the premiere edition of Specialty & Custom Chemicals America trade fair which will take place in the charming and captivating with its Western heritage City of Cowboys and Culture, Fort Worth, located in the center of the Texas State.

This event will focus on the products and technologies that find applications across a various range of specialty and custom chemical end-uses including: agriculture and crop protection, pharmaceuticals, flavors and fragrances, plastics and composites, polymers, monomers, cosmetics, detergents, adhesives, sealants, resins, fuels, biofuels and lubricants, as well as mining and mineral processing.

Trade shows exhibitors and attendees will have opportunities to gain new contacts and to build business relationships with existing and new partners on the new point on the map of events associating together specialists of the chemical industry.

We cordially invite you to visit our exhibit space No. 711 where our staff will be happy to provide you with detailed information about products and services offered by Apeiron Synthesis.


We are pleased to announce that our CTO Krzysztof Skowerski will represent Apeiron with lecture on Stable Carbene Symposium, which will take place on the November 30th, 2018 in Toulouse, France at the University Paul Sabatier (Auditorium Marthe Condat). This event is organized on the occasion of the 30th anniversary of the stable carbenes discovery.

Prolongly regarded as chemical curiosities since they defy the octet rule, carbenes have become common functional groups. Due to their unique properties and broad range of possible applications in homogeneous catalysis, both as organocatalysts and as ligands for transition metals they are considered as one of the most valuable tools in organic, inorganic and organometallic chemistry. They are also increasingly applicable in medicinal chemistry and material science.

This symposium is aiming to gather chemists working on or interested in stable carbenes, and to promote exchange on the developments in carbene chemistry and share researchers latest results. Symposium agenda will consist of nine lectures given by prominent invited speakers. We are proud that Krzysztof Skowerski is also included in this list of the experts of the field.


We are delighted to announce that our products had been placed in Merck’s worldwide catalogue. MERCK KGaA, who acquired Sigma Aldrich is a reputable, globally-expanded company, aiming to “solve the toughest problems in life science by collaborating with the global scientific community” and we are happy to work with them as our products distributor. Currently available catalysts in Merck’s offer are as follows: Nitro-Grela, Nitro-Grela 1. generation, nitro-Grela SI -o-Tolyl, nitro-Grela-I2, GreenCat iPr, AquaMet, StickyCat PF6 and metal scavenger SnatchCat.

This introduction makes our olefin metathesis process promptly accessible to chemists around the world, which allow them to take advantages created by this valuable and efficient catalytic technology, applicable in a broad-spectrum of industries. Usage of our catalysts provides a competitive edge over the conventional methods of synthesizing molecules including, among others, lower catalyst loading and volume of solvent, higher reaction concentrations, reduced amount of by-products and wastes, easy post-reaction ruthenium removal - providing time and money saving solutions.

Now we are working together on implementation of some additional metathesis catalysts. In the near future we are expecting Merck’s offer of Apeiron’s catalysts to be broader.

Apeiron Synthesis is glad that Merck will contribute towards spreading our company's mission of transforming chemistry!


This year the annual summer Symposium will take place in Tokyo, Japan from 26 to 27 July. JSPC was founded in 2001, they are hosting the symposias twice a year (summer and winter edition). Members of JSPC belong to pharmaceutical and chemical industries, manufacturers of pharmaceuticals intermediates and universities. The 2018 meeting will feature invited lectures that span topics of process chemistry, total synthesis, chemical biology, catalysis, methodology development and reaction mechanism. Our own, Senior Scientist, Andrzej Tracz will have a presentation entitled “Process Oriented Olefin Metathesis – Development and Application of Cyclic Alkyl Amino Ruthenium Complexes”. We encourage everyone to attend his talk.

The 2018 Gordon Research Conference on Organic Reactions and Processes (ORP) will convene established and up-and-coming experts in synthetic organic chemistry at Stonehill College, MA July 15-20, 2018. This 64th consecutive annual gathering will focus on real world examples at the forefront of target-oriented synthesis, mechanism elucidation in bond-forming reactions, and fundamental discoveries in molecular reactivity. The meeting sessions will feature a diverse lineup of international experts in organic reaction development and synthetic strategy who hail from Asia, Europe, and the Americas. You can meet there Dr. Grazyna Szymanska and Dr. Anna Gawin representing Apeiron with a poster describing “Development and optimization of synthesis and the production launch of a new generation of ruthenium-based, olefin metathesis catalysts”. We are looking forward to inspiring discussions!

This year Chemspec Europe – The fine & specialty chemicals exhibition is taking place in Cologne on the 20-21 June. Chemspec will be great occasion to meet Apeiron`s representation and learn more about the newest advances in olefin metathesis. Our CEO Dr Michał Bieniek will be presenting at “Innovative Startups: New Paths to Fine and Specialty Chemicals”. We encourage everyone to attend his talk in the Agrochemical Lecture Theatre, June 20 at 14:45.

To learn more about our products and services please come and visit us at the stand J67 – Dr Michał Bieniek, CEO; Joanna Drygajlo, Sales Manager and Agnieszka Roszyk, Sales Representative will be happy to explore possibilities of cooperation with you.

Very interesting article was published in Green Chemistry where Szczepeniak et al. introduced a method of removal of ruthenium residues which is time economical, cost-effective and scalable. This is important issue for pharmaceutical industry where all process development groups have to make sure to have less than 10 ppm of the residual metal in the product. Method simple as treatment of postreaction mixtures with a SnatchCat (AS1033) and then with acid followed by a filtration is shown to yield olefin metathesis products with ruthenium contamination below 5 ppm even in highly challenging cases. Moreover you can find a telescope RCM/Suzuki–Miyaura sequence with a rapid and efficient purification protocol for simultaneous removal of Ru and Pd residues from solution. You can find the article here

Recently, Daniel B. Wright et al. have reported aqueous-phase Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA) for forming well-defined micellar polymer nanoparticles. This was achieved with our AquaMet (AS2038) which is a water-soluble cationic Hoveyda-Grubbs type second generation catalyst. The reaction conducted in water produced diblock copolymers from norbornenyl monomers, which then was selfassembled into myriad nanostructure morphologies. If you are more interested in the detailed information about polymerization in water with AquaMet check the whole article here

Do not miss Beilstein Organic Chemistry Symposium, “Tomorrow's Catalysis for Research and Industry” that is taking place on 24 – 26 October 2017 in avendi Hotel am Griebnitzsee, Potsdam, Germany. The symposium  has been inspired by the Thematic Series “Progress in metathesis chemistry II” in the Open Access Beilstein Journal of Organic Chemistry, edited by Karol Grela. It covers essential aspects of catalysis i.e. catalytic reactions in research and production , development of new organo- and metal-based catalysts, immobilized transition metal complexes as industrial catalysts, elucidation of mechanism of catalytic reactions, green and sustainable catalysis. Among outstanding invited speakers from both industry and academia you will find Krzysztof Skowerski representing Apeiron. Additionally, you can meet Katarzyna Kaczanowska presenting a poster and our CEO, Michal Bieniek.


We always look forward to the Organic Process Research and Development event organized by Scientific Update. This time it takes place in the charming city of Stockholm, Sweden, September 27-29, 2017. What we really appreciate about OPRD is that the speaker selection continues to match perfectly expectations of an industrial audience. Discussions will relate to synthetic route design, development and optimization in the pharmaceutical, fine chemical and allied fields. The event gives plenty of opportunities to meet and network with speakers and fellow attendees during the reception, sit-down lunches and extended coffee breaks in a relaxed and informal environment. Apeiron’s delegate, Katarzyna Kaczanowska will be happy to meet with you and share thoughts on today’s challenges.


This year marks 63rd consecutive gathering for Organic Reactions & Processes Gordon Research Conference that will take place in Stonehill College, Easton, MA on July 23-28. The event attracts annually a diverse group of scientists from both industry and academia who are eager to learn about recent fundamental discoveries in organic synthesis first hand from scientific pioneers. The 2017 meeting will feature invited lectures that span topics of process chemistry, total synthesis, chemical biology, catalysis, methodology development and reaction mechanism. In addition to the exciting lineup of speakers, this conference also features outstanding and highly energetic poster sessions. You can meet there Dr. Katarzyna Kaczanowska representing Apeiron with a poster describing “Development of Bis-(Cyclic Alkyl Amino Carbene) Ruthenium Complexes, a Versatile and Highly Efficient Catalysts for Olefin Metathesis”. We are looking forward to inspiring discussions!


Symposium on Olefin Metathesis and Related Chemistry (ISOM XXII) is taking place this year in Zurich, Switzerland, July 9 to 12. We are thankful to the organizers for their kind invitation and are pleased to have such a great opportunity to present some of Apeiron’s research. Apeiron’s CTO, Krzysztof Skowerski, will hold a talk entitled “New catalysts for olefin metathesis “on the second day of the meeting.

Apart from catalyst development, the event is strongly focused on metathesis applications in chemical industries including pharmaceutical, polymer and renewables sector. Not surprisingly, the topics along with outstanding speaker panel (including Nobel prize winner, Richard Schrock) attracts both academia and industry. Based on our previous ISOM experiences, this year too we expect many vivid discussions and we hope to meet you there.


Chemspec Europ 2017 which this year is taking place in Munich on the 31 May – 1 June will be a great occasion to meet Apeiron team and hear a little bit more about the latest advances in catalytic olefin metathesis. Our own Dr Katarzyna Kaczanowska will be presenting on the 1st June at 14:45 in Pharma Lecture Theater new catalysts development and their exceptional efficiency and Dr Michal Bieniek CEO will give a short talk presenting the company at the ‘ Innovative Start-ups: New Chemicals & Industrial Biotechnology’ in the Agro Chemical Lecture Theatre at 13:45.

To learn more about our products and services please come and visit us at the stand R102 - Michał Bieniek, CEO; Joanna Drygajlo, Sales Manager and Katarzyna Kaczanowska, Senior Research Manager will be happy to explore possibilities of cooperation with you.


The 2nd Annual Catalysis in Chemistry Symposium made its mark on the chemistry world. We were pleased to gather roughly 80 chemists in the Boston Marriott Cambridge who were attracted by 8 outstanding presenters describing state-of-the-art science and 9 as impressive posters. Along the way, much chemistry was discussed, new connections emerged and old relationships were strengthened.

We would like to thank once again the speakers and all the attendees. Hopefully you enjoyed the event as much as we did. The Apeiron Team is already thinking about the next edition and we are looking forward to seeing you all again.

In the photo: Apeiron Team with the speakers (Nizar Haddad, Krzysztof Skowerski, David A. Conlon, Timothy Donohoe, Deryn Fogg, L.-C. Campeau, David Leitch and Joel Hawkins).


Its back! The 1st annual Catalysis in Chemistry Symposium was a huge success - we were a little ambitious in suggesting the inaugural event would be an annual one, but participants have enthusiastically urged us to keep it going. so here it is, bigger (a little) and once again, featuring a stellar roster of speakers from Pharma and Academia to share the latest greatest accomplishments and trends in catalysis (in synthetic chemistry).

The following speakers will be giving lectures on their latest research results:

Louis- Charles Campeau - Merck
David Conlon - Bristol Myers Squibb
Timothy Donohoe - University of Oxford
Deryn Fogg - University of Ottawa
Joel Hawkins - Pfizer
Chris Senanayake - Boehringer Ingelheim
Krzysztof Skowerski – Apeiron Synthesis
Matthew Tudge - GlaxoSmithKline

Don't miss out on such an occasion an register here and now


Exciting news! Apeiron’s team has developed bis-(CAAC)Ru indenylidene complexes for olefin metathesis, which was recently published in Angewandte Chemie (CAAC stands for cyclic alkyl amino carbene). The unique feature of these catalysts is that they are extremely effective in the formation of both terminal and internal C=C bonds; TON exceeding 300000 was achieved. Until our discovery the state-of-the-art in olefin metathesis has been the application of N-heterocyclic carbene (NHC) containing ruthenium alkylidenes for the formation of internal C=C bonds and of cyclic alkyl amino carbene (CAAC) containing ruthenium benzylidenes in the production of terminal olefins. As such our new catalysts combine the scope previously shared between these two catalyst families. You can find the article here.


We are delighted to announce that two new catalysts HeatMet and FixCat are now available via Strem.

HeatMet represents an excellent tool for precise ROMP control. This catalyst at 20 ppm loading and temperatures above 60C affords quantitative yields of poly(DCPD).

FixCat was developed as a versatile catalyst for efficient homo- and heterogeneous systems. Additionally, it falls into the section of our supporting technologies: Apeiron’s metal scavenging solutions. Together with SnatchCat scavenger this catalyst facilitates purification of the metathesis products from residual ruthenium. To find out more please see our brochure - PDF. We strongly believe that our customers will be able to further accelerate the progress of research development in their respective domains by deploying our expanded line of products.


We are happy to see that advantages of Apeiron’s catalysts are being noticed also in the academia. Researchers at Jagiellonian University Medical College and Universite de Montpellier lead by Frederic Lamaty have published a comprehensive study presenting ring-closing metathesis (RCM) approach towards synthesis of substituted pyrroles. The study included evaluation of metathesis catalysts where Apeiron’s nitro-Grela outperformed the competition in the majority of tested reaction conditions. Importantly, obtained series of 2-aryl-1H-pyrrole- 3-carboxylates represent an attractive building block, particularly in the context of CNS-oriented compound libraries. To learn more about the topic please access the publication (Tetrahedron 2016, 72, 7462-7469)


Yet another leading process chemistry conference organized by Scientific Update – The Organic Process Research and Development. This time the event takes place in our direct neighborhood - in the charming city of Prague. We wouldn’t miss such great opportunity! Apeiron’s delegates, Dr Katarzyna Kaczanowska and Joanna Drygajło will be there to learn from the industry leaders and to network with a fine selection of their chemists.

As always, the list of speakers is long and impressive and the topic selection emphasizes catalytic processes. We are looking forward to the Johnson Matthey workshop where the experts will give us insights into the latest advancements in catalysis technologies.

If you are attending the meeting as well please drop by our booth.


In just few days , on October 4-6th in Barcelona takes place CPhI Worldwide. This world's largest pharma trade show is recognized as one of the best places to network with more than 36,000 pharma industry professionals from 150+ countries. As such it connects people within the pharmaceutical sector and creates opportunities to source new suppliers, build relationships with existing partners and identify new business opportunities. Apeiron will have a strong delegation at this year’s event. Apeiron’s founders Michal Bieniek and Lukasz Gulajski along with the team members, Joanna Drygajlo, Andrzej Tracz and Katarzyna Kaczanowska are looking forward to seeing you in Barcelona.


Cambridge, Ma - Apeiron Synthesis and Snapdragon Chemistry announced they have signed a Memorandum of Understanding (MOU) regarding exploration of opportunities to collaborate. Snapdragon and Apeiron offer complementary specialist services to the pharmaceutical and chemical industries that are focused on increasing efficiency and lowering costs for their customers.

In signing the MOU, Apeiron and Snapdragon agree to co-promote each company’s respective services and technologies and will seek to develop new business opportunities where the combined capabilities of both companies will offer significant benefit to the customer. According to Matthew Bio, CEO of Snapdragon, “Our chemists and engineers are excited about the prospects of integrating more metathesis applications in our work. The tremendous efficiency of metathesis chemistry is a perfect match for the innate efficiency of continuous flow processes.”

Both companies are committed to meeting the needs of customers and business partners as their highest priority and will endeavor to cooperate where the combined technologies are in the best interests of the customer. Michal Bienek, CEO of Apeiron Synthesis said: “We’re confident that our command of olefin metathesis chemistry, combined with Snapdragon’s sophisticated flow chemistry process development capabilities, will provide enormous economic advantages for clients.”

Snapdragon and Apeiron will be represented at the 252nd American Society National Meeting and Exposition in Philadelphia, PA on August 21-25. All in attendance are welcomed to visit at booth 316 and don’t miss Matthew Bio’s presentation on 22 August: “SCHB 20: Exploring new frontiers in chemistry through advanced manufacturing technologies”


Apeiron Synthesis is delighted to announce that Tokyo Chemical Industry (TCI) provides Apeiron’s nitro-Grela olefin metathesis catalyst (Apeiron Cat. No. AS2032) as product N1060 and AquaMet (Apeiron Cat. No. AS2038) as product A3009 in TCI’s worldwide catalogue. With the introduction of Apeiron’s flagship catalyst in TCI’s catalog, both companies are now working toward rolling out additional catalyst products to offer chemists ready access to the right catalyst for their chemistry. At the same time Apeiron’s Aquamet catalyst (Apeiron Cat. No. AS2038) is available through TCI’s catalogue as product A3009. As noted by Michal Bieniek, Apeiron’s CEO, “One of our key goals is to make olefin metathesis, a remarkable atom efficient carbon-carbon bond forming reaction, one of the top choices for chemists synthesizing complex molecules. We can only do this by making our efficient, reliably robust, broad range of catalysts available to chemists worldwide. With its global presence, and especially strong reputation in Japan and Asia, TCI is an excellent partner for us.”

About TCI: TCI (Tokyo Chemical Industry) is a leading, Japan-based manufacturer of specialized research chemicals and bulk chemicals. The company’s product portfolio contains more than 26,000 products, including more than 9,000 products unique to TCI in the global market. The majority of these chemicals are manufactured at TCI’s facilities in Japan. With more than 90% of TCI’s products in stock, TCI can ensure prompt delivery. TCI’s products are dedicated especially to researchers engaged in synthetic chemistry, bioscience, glycoscience, materials chemistry, catalysis and analytical science, as well as other research fields. Additionally, TCI provides custom solutions including contract synthesis and bulk manufacturing.

About Apeiron Synthesis: The mission of Apeiron Synthesis is to fully realize the potential of olefin metathesis in synthetic chemistry, with efficient and cost-effective solutions for R&D and commercial manufacturing processes – solutions that can benefit a wide range of industries, including agrichemicals, fine chemicals, flavor and fragrances, polymers and Pharma/Biopharma. Catalytic olefin metathesis technology offers chemists remarkable efficiency over traditional methods for building complex molecules - fewer synthetic steps and byproducts, reduced waste, and higher reaction concentrations - significantly lowering costs. Apeiron has developed a growing portfolio of over twenty high performance metathesis catalysts, available in milligram to multi-kilogram quantities, designed to accommodate a wide range of applications. With an uncompromising commitment to the design and use of robust new catalysts, our team of specialists is available to help customers transform their chemistry with metathesis technology. Apeiron is leading the way to diverse new applications to transform catalytic olefin metathesis from a technology with high potential to an important part of every chemist’s toolkit.


Apeiron Synthesis will soon be on the road again. We will be exhibiting at the 252nd American Chemical Society National Meeting and Exposition. This Fall 2016 National meeting will be held in the Philadelphia Convention center, 21-25 August 2016, and the exhibition center will be open the evening of Sunday the 21st through the end of day on Tuesday the 23rd of August. Apeiron will be at booth number 316. Please stop in to say hello; we're looking forward to catching up with old friends and business partners and to meeting lots of the chemists who will be attending this great event in the birthplace of the USA.

Apeiron Synthesis designs and manufactures robust, highly effective olefin metathesis catalysts for applications from R&D to commercial production. Apeiron’s chemistry team is comprised of experts in metathesis who work with partners to rapidly optimize their metathesis-based processes. Catalysts are available in specialized kits and individually, from mg to hundreds of kg quantities.


In the latest issue of Speciality Chemicals Magazine Katarzyna Kaczanowska and Krzysztof Skowerski present an approach towards robust and efficient olefin metathesis. The article entitled “New Tools for Olefin Metathesis Transformations” summarizes some of Apeiron’s solutions that address encountered process difficulties. Customized catalysts and supportive technologies, such as metal scavengers or reactors for continues flow processes, are some of the developments outlined in the review. We hope that you will enjoy the read! Please share it with colleagues and give us your feedback.

The article is available online hereLINK


Chemspec Europe 2016 is the international exhibition for fine and speciality chemicals. The 31st edition of this highly successful industry event will take place from 1–2 June 2016 in one of Europe’s major hubs for the industry, Basel in Switzerlad. For the first time Apeiron will have a strong technical and sales team in place.

This year we will focus on our new products and applications such as heterogeneous catalyst and metal scavengers. Our catalysts are designed to enable for the first time metathesis in continuous flow. For some applications we achieved lower than 50 ppm catalyst loading and TON above 90,000. As expected, they lead to products with ruthenium levels comparable or lower to those obtained with scavengers present at the purification step, (i.e. below 1 ppm).

Please come and visit us at the stand E102 - Michał Bieniek, CEO; Joanna Drygajlo, Sales Manager and Andrzej Tracz, Senior Scientist will be happy to explore possibilities of cooperation with you.

We are proud to announce that our 1st Catalysis in Chemistry Symposium was a great success. The outstanding line-up of speakers ensured hight level of the lectures and created a platform to discuss such important matters as practical applications of catalysis.

We would like to thank once again all the spekers and all the guest. Hope to see you all next year.

To know more about the event please see more detailed summury written by Roger Frechette (Apeiron)LINK

And here you will find a closing remarks from Dr David Conlon (BMS)LINK

In the photo from left to right: Seb Caille, Roger Frechette, Michal Bieniek, Chris Senanayake, Kasia Kaczanowska, Eric Jacobsen, Jin-Quan Yu, Krzysztof Skowerski, Jim Morken, Grazyna Szymanska.

A leading global business event for personal care ingredients, In-cosmetics, will take place this year on 12-14 April in Paris, France. With over 700 exhibitors representing world's leading suppliers, manufacturers and R&D specialists, this exceptional event gives a great chance for networking and new business opportunities. One can fine here the industry leaders such as Givaudan, IFF, Symrise or Takasago.

We will be there as well. Please find out our delegates at In-cosmetics! Apeiron is eager to introduce you to out cutting edge technologies developed specifically for the personal care ingredients industry.



Apeiron would not miss and outstanding event such as 33rd SCI Process Development Symposium. Organized by SCI's Fine Chemicals Group the meeting takes place in Churchill College, Cambridge, UK on April 6-8, 2016.

Process development continues to be a challenging and important area enabling implementation of modern synthetic organic chemistry. The symposium brings together a wide range of speakers and delegates from across the Pharmaceutical, Agrochemical and Fine Chemical industries, as well as from an academic background.

This is an excellent opportunity for networking between like-minded process scientists of all levels of experience and from all areas of the chemical industry. Please find Apeiron's delegates Joanna Drygajło (Sales Manager) and Katarzyna Kaczanowska (Senior Research Manager) who are looking forward to meeting you!


Apeiron Synthesis is delighted to announce that registration is open for the Catalysis in Chemistry Symposium to be held at the Royal Sonesta Hotel in Cambridge, MA on April 28, 2016. Please join us for what promises to be a full day of great science and networking.

This year Symposium which will bring together the best catalysis group from Big Pharma (Amgen, Boehringer Ingelheim, Bristol Myers Squibb) as well as Academia (Harvard, Scripps Research Institute, Boston College).

For more information and registration go hereLINK


Strem Chemicals published a new 'Product Blog' post: "Efficient, Durable and Reusable Catalysts that Can Operate Under Demanding Condition" describing Apeiron's core catalysts, the initial group of our catalysts available through Strem.

This post nicely summarizes a detailed description of Apeiron's catalysts in action in a previously published The Strem Chemiker. Additional information can be found in the Strem Catalog and on Apeiron's Catalysts page. Of course, if you have questions regarding how our products or metathesis team can help to address challenges in your lab, we would be delighted to hear from you. Feel free to contact us here, or send email This email address is being protected from spambots. You need JavaScript enabled to view it.

At Apeiron we are committed to continuous development to facilitate the usage of olefin metathesis technology for our clients. That is why we are planning to extend our current catalyst offering at Strem, with four new products coming soon and an extensive rollout of catalysts scheduled over coming months.

Stay tuned!


February 26, 2016: Apeiron is hosting a networking lunch at MassBio's headquarters in Cambridge, MA. to introduce the company to the Massachusetts life sciences community. Beginning with registration and networking at 11:00AM, Apeiron's leading chemists, Kasia Kaczanowska, Sr. Research Manager, and Krzysztof Skowerski, Chief Technology Officer, will be available on site until 2:00PM to meet area chemists and biotech executives. Kasia and Krzysztof will also present a brief overview of Apeiron's product and services: "Not your Father's Metathesis Catalysts". As MassBio members since 2015, the Apeiron Team is looking forward to exploring new relationships in the MA life sciences ecosystem.

We will be happy to see you there. For pre-registration please go toLINK


The MassBio CRO/CMO Symposium was held in Boston on November 13. This 4th annual iteration of CRO/CMO Symposium, a MassBio Signature Event, attracted more than 330 attendees to discuss the critical role that the MA CRO/CMO community plays in shortening time to market for life sciences companies. Bookended by two keynote addresses, a series of interactive panel discussions and roundtables along with networking sessions, provided an unparalleled opportunity to explore the various techniques and approaches being used by both virtual and established companies to take advantage of this community.

In addition to being exhibitors, Apeiron was chosen to present in the New Technology Showcase, a new feature for the CRO/CMO Symposium. Grazyna Szymanska, Vice President Global Business Development (from our Cambridge office) presented Apeiron’s solutions for “Faster, Cheaper and Greener Chemistry”.

The strength of Apeiron’s technology was further spotlighted in an article introducing the New Technology Showcase, published in the Boston Business Journal - by Don Seiffert,

Bioflash Editor:LINK


Apeiron will be participating in ChemOutsourcing, September 14-17, 2015 in Long Branch, U.S. ChemOutsourcing is the largest U.S.-based API event attracting annually hundreds of chemists and business development personnel from the pharmaceutical, biotech and chemical industries.

This year we will focus on our new products and applications such as heterogeneous catalyst and metal scavengers. Our catalysts are designed to enable for the first time metathesis in continuous flow. For some applications we achieved lower than 50 ppm catalyst loading and TON above 90,000. As expected, they lead to products with ruthenium levels comparable or lower to those obtained with scavengers present at the purification step, (i.e. below 1 ppm).

Find out more about our new catalysts and scavengersLINK

Apeiron’s booth will be staffed by our senior technical people, as well as sales representatives so you can directly inquire about new products and technologies.

Michal Bieniek, CEO, Grazyna Szymanska, VP of Global Business Development, and Joanna Drygalo, Sales Manager and Technical Support, are looking forward to meeting you!


Yet another significant step towards accelerating Apeiron’s innovation; our company has officially become a proud member of The Massachusetts Biotechnology Council (MassBIO). Founded in 1985 in one of America’s top technology centers- Cambridge Massachusetts, MassBio connects over 650 members; approximately 60 % are biotech companiesLINK

With the organization’s noble goals, i.e. advancing the development of critical science, technology and medicines that benefit people worldwide, it created a unique network of people that want to make a difference. Multiple events organized by MassBio such as MassConnect or PharmaDays, facilitate connecting decision-makers and strategic partners, a critical aspect that drives innovation.

From Apeiron’s perspective, with its continuously growing repertoire of innovative products and technologies, MassBio creates perfect opportunities to execute our company’s goal i.e., to build value for our customers while creating a competitive advantage.


July 13-15, 2015 in Toronto, Canada will take place a leading process chemistry conference, Organic Process Research & Development. This exceptional, industry-oriented event attracts top international speakers. One can hear about efficient transfers of laboratory methods into manufacture processes on tonnage scale from key players in the chemical and pharmaceutical industries. This includes companies such as Dow Corning Corporation, Genentech Inc, and Pfizer Inc.

We are very excited to participate in the conference and the side events. At the organized exhibition you can find Apeiron’s booth where our representatives, Joanna Drygalo and Grazyna Szymanska, will introduce you to our innovative technologies, including heterogeneous catalysts fully compatible with continuous flow application.

You can find more information about the event here:LINK


At Apeiron Synthesis we are committed to create technologies and processes that are functional, cost-effective, and environmentally benign while employing olefin metathesis.

In a recent article published by Strem in the Chemiker entitled: Olefin Metathesis: New Catalysts, New Solutions for Process Chemistry readers will find an in depth overview of catalysts developed by Apeiron which make development of metathesis-based processes feasible and cost-effective.

The article, starts out by describing an interesting case in which our catalyst has been employed for the synthesis of Hepatitis C protease inhibitor for Boehringer Ingelheim (making this the first example of a truly practical RCM macrocyclization) and then moves on to discuss latest developments in the area of heterogeneous catalysts.

As described in the article, efficient heterogeneous catalysts provide excellent opportunities for design of continuous flow processes and present exceptionally easy synthesis of products with very low amounts of residual ruthenium. The low loadings achievable with our robust catalysts create possibilities for application of olefin metathesis within a broad range of sectors in the chemical industry.

To download our free manuscript please goes to:LINK
More information about our homogenous and heterogeneous catalysts could be found at:LINK

To purchase our core catalysts for R&D purpose please go to Strem catalogue at: Description of Apeiron’s catalysts sold by Strem could be found also at:LINK

To purchase any of our catalysts for manufacturing purpose please go directly to:LINK



On 24-26 March 2015, the eighteen partners from 9 different countries involved in the EU funded research project COSMOS “Camelina & crambe Oil crops as Sources for Medium-chain Oils for Specialty oleochemicals” held their kick-off meeting in Wageningen, The Netherlands. Led by Wageningen UR Food & Biobased Research, this project aims at reducing the dependence of Europe’s oleochemical industry on imported plant oils by turning camelina and crambe into profitable, sustainable, multipurpose, non-GMO European oil crops. COSMOS was on the top of the list of the new Horizon 2020 granted programs.

The project is aimed on implementation of newest technologies, and represents a leading example of tight collaboration between industry and science.

From eighteen partners involved nine of them are SME’s and large companies, while the other half are universities and research institutions. Apeiron Synthesis together with other industry leaders will be involved in development of new enabling technologies which would turn domestic oil crops into viable source of for medium-chain fatty acids (MCFA, C10–C14) and medium-chain polymer building blocks for the production of plastics, surfactants, detergents, lubricants, plasticizers as well as other oleochemicals. For more details please go toLINK


This year ISOM co- sponsored by Apeiron-Synthesis and will be held at the facilities of Graz University of Technology (also in Germany). Following a traditional series of symposia, the upcoming one will cover the following topics:

  • Catalyst development and Organometallic Chemistry of carbenes and carbynes.
  • Application of Olefin Metathesis in Organic and Pharmaceutical Chemistry.
  • Application of Olefin Metathesis in Materials and Polymer Chemistry.
  • Application of Olefin Metathesis in sustainable use of renewable resources.
  • Olefin Metathesis related chemistries.

A balanced composition of plenary, invited and contributed lectures, as well as poster presentations will allow for a deep insight into the latest developments in the field. For more information please go to:LINK

Our team will be there including the CTO This email address is being protected from spambots. You need JavaScript enabled to view it., so please contact him directly to schedule a meeting or inquire about our products or new applications, especially our latest heterogeneous catalysts optimized for continuous flow conditions.

Please note that the invited lecture will be given by our Scientific Advisor Prof. Karol Grela


Next month, the most important Polish event in its chemical sector, the Congress of Polish Chemistry organized by The Polish Chamber of Chemical Industry will take place in The Scientific and Technological Park in Puławy. This event gathers key players from the Polish Chemical market such as Grupa Azoty, Orlen, Lotos, as well as a number of global chemical companies. Last year’s Congress was attended by Dr. Kurt Bock, CEO of BASF, and it will be sponsored by BASF this year as well.

The major issues to be discussed at the upcoming congress are: environmental protection, global perspectives of the chemical industry, and a role of financial sector in the development of chemistry.

We are the only small size company invited there to brain storm with big industry players. Steve Jobs once said “Innovation distinguishes between a leader and a follower.” We are proud to let you know that our CEO Dr. Michał Bieniek will also be participating in the panel discussion entitled “Innovations - the needs of the Polish chemical industry”.

If you are in the neighborhood come and have a word with us!

You can find more information about the event here:LINK


Last year our advisor, Professor Karol Grela received the highest scientific award from the Foundation for Polish Science (FNP).

This award recognized Professor Karol Grela for developing new catalysts for olefin metathesis reactions and applying them in industrial practice.

Scientific achievements of prof. Karol Grela include over 120 scientific publications and 12 patents protected in a few dozen countries around the world. His research has found many practical applications. He works closely with the pharmaceutical industry, and is a member of Polpharma S.A.’s Scientific Advisory Board among other posts.

During the award ceremony the Minister of Science prof. Lena Kolarska-Bobińska, said:
“The winners were the best of the best. Awards Foundation reaches the hands of great scholars whose scientific work not only exceeds the limits of existing knowledge, but also is an example of excellence in science”.

We would like to congratulate prof. Grela once again. We are extremely proud of having him by our side!

Keep up the good work!

To find out about the latest book edited by prof. Grela “Olefin Metathesis: Theory and Practice” please read our note below.


During the last few decades, olefin metathesis has gained considerable importance in modern synthetic chemistry as a preferred methodology for manipulation of carbon–carbon double bonds, offering an attractive and simplified alternative to traditional methods for synthesizing complex organic molecules and polymers.

Worldwide importance of these findings was recognized by the award of the 2005 Nobel Prize to Y. Chauvin, R. R. Schrock, and R. H. Grubbs. Their major achievements and other relevant developments in the field were described in the comprehensive three-volume Handbook of Metathesis edited by R. H. Grubbs and published in 2003. Since then, continuing growth of the field has justified a publication of the new single-volume book edited by Professor Grela. This book is a perfect companion for every chemist who wishes to enter the “change partner’s dance” of double bonds.

Professor Karol Grela has been recently awarded Prize of Foundation for Polish Science (FNP), the so called “Polish Nobel Prize” (for more details please see our note above)

The last but definitely not least important chapter of this book, “Purification Strategies in Olefin Metathesis”, is written by two members of Apeiron’s scientific team – Lukasz Gułajski and Krzysztof Skowerski.

The authors describe most effective methods of removal of residual ruthenium from crude metathesis products in view of their commercial applications and industrial experiences. A possible choice between scavengers and modified solid-supported catalysts is widely described and their respective advantages and disadvantages are discussed.

To purchase a book Olefin Metathesis: Theory and Practice - by Karol Grela please go to: please go to:LINK



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Joanna Drygajło
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Global Business Development
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