A novel application of our efficient scavenger and quenching agent – SnatchCat shown in the recent publication
Szczepaniak et al. have reported a study on quenching and effective removal of copper residues after Cu/TEMPO-catalyzed aerobic alcohol oxidation (Stahl oxidation) and atom transfer radical polymerization (ATRP). The article was published in Chemical Science and the study is based on Apeiron’s commercially available product – SnatchCat (1,4-bis(3-isocyanopropyl)piperazine).
The results presented in this study showed that SnatchCat can be used as a highly efficient copper scavenger in the purification of Cu/TEMPO alcohol aerobic oxidation products, being able to purify both small and macromolecules. It can also be used for polymers purification produced by Cu-catalyzed ATRP. Referring to both analyzed reactions, the addition of SnatchCat followed by the application of simple purification protocols resulted in very low Cu content below 5 ppm in isolated aldehydes as well as in polymers, even after ATRP with high catalyst loading.
Another advantage of our product exhibited therein, is that it rapidly stops copper-mediated reactions, facilitating the kinetic studies and reaction design or copper removal by filtration. Moreover, the authors also demonstrated that SnatchCat could be successfully used to prevent side reactions. It completely prevented the Glaser coupling under oxidative conditions occurring during polymers workup.
The cytotoxicity of Apeiron’s scavenger and quenching agent has also been examined. Although isocyanide proved to be moderately cytotoxic, it could be easily neutralized by acid hydrolysis.
If you would like to learn more about the applicability of SnatchCat in two fundamental reactions catalyzed by copper complexes, please refer to the whole open access article here.