Check out another interesting application of our AquaMet catalyst in pioneer synthesis of unprotected peptides in water!


The article written by S. Masuda et al. has been recently published on journal Organic & Biomolecular Chemistry, showing the results of their research on the synthesis of unprotected peptides in water by ring-closing metathesis (RCM).

Although RCM is an attractive reaction for the preparation of artificially designed peptides, the article entitled “Ring-closing metathesis of unprotected peptides in water” was the very first report of the possibility of unprotected peptides synthesis in water in the presence of Mg (II) ions, without the addition of any organic solvents in RCM which was achieved using a water-soluble ruthenium catalyst – AquaMet, produced by Apeiron Synthesis.

Authors have carried out the optimization of the reaction conditions and showed that the addition of MgCl2 and/or the use of acidic conditions enables the efficient RCM of unprotected model peptides and octreotide analogues in water. That proposed method, the first non-disulphide type connection reaction between homo functionalities in water, with the usage of our catalyst could become a cornerstone of artificial bioactive peptide mimetics development in future.

The full version of article available: here